I-8-Hydroxyquinoline (8-HQ)
Impahla: 8-Hydroxyquinoline (8-HQ) enekhwalithi ephezulu
I-CAS#:148-24-3
Ifomula Yamamolekyuli: C9H7NO
Ifomula Yesakhiwo:
Ukusetshenziswa: Izinto ezihlanganisa imithi; Izinto ezihlanganisa imithi yokubulala izinambuzane kanye nezinto ezihlanganisa imibala
Imininingwane:
| Into | Okujwayelekile |
| Ukubukeka | Cishe i-crystalline powder noma amakristalu anombala omhlophe noma onsundu okhanyayo |
| Iphunga | I-Phenolic |
| Isixazululo (10% ku-alc) | Kucacile cishe |
| Izinsimbi ezisindayo | ≤20ppm |
| Izinsalela ezivuthayo | ≤0.2% |
| Insimbi | ≤20ppm |
| Uhla lokuncibilika | 72-75℃ |
| I-Chloride | ≤0.004% |
| I-Sulfate | ≤0.02% |
| Ukuhlolwa | 99-99.8% |
| 5-Hydroxyquinoline | ≤0.2 % |
Ukuqedwa
Incibilika ku-ethanol, i-acetone, i-chloroform, i-benzene kanye ne-mineral acid, cishe ayincibiliki emanzini.
I-8-hydroxyquinoline iyi-amphoteric, inyibilika kuma-asidi aqinile kanye nezisekelo, ihlanganiswe kuma-ion angalungile ezisekelo, iboshwe kuma-ion e-hydrogen kuma-asidi, futhi inokuncibilika okuphansi kakhulu ku-pH = 7.
Ukusetshenziswa okuqondile
1. Njenge-medicine intermediate, akuyona nje kuphela into eluhlaza yokwenziwa kwe-kexieling, i-chloroiodoquinoline ne-paracetamol, kodwa futhi iyi-intermediate yamadayi nezibulala-zinambuzane. Lo mkhiqizo uyisithako esiphakathi kwemithi ye-quinoline anti amoeba ene-halogenated, okuhlanganisa i-quiniodoform, i-chloroiodoquinoline, i-diioquinoline, njll. Le mithi idlala indima yokulwa ne-amoeba ngokuvimbela amagciwane ahambisanayo emathunjini. Isebenza kahle ekushayweni yisisu kwe-amoeba futhi ayinawo umthelela kuma-protozoa e-amoeba angaphandle kwamathumbu. Kubikwa kwamanye amazwe ukuthi lolu hlobo lomuthi lungabangela i-subacute spinal cord optic neuropathy, ngakho-ke ivinjelwe eJapan nase-United States. I-Diioquinoline ibangela lesi sifo ngaphansi kwe-chloroiodoquinoline. I-8-hydroxyquinoline nayo iyi-intermediate yamadayi nezibulala-zinambuzane. I-sulfate yayo kanye nosawoti wethusi kuyizinto zokugcina ezinhle kakhulu, izibulala-magciwane kanye nama-anti mildew agents. Lo mkhiqizo uyinkomba ye-complexometric yokuhlaziywa kwamakhemikhali.
2. Njenge-ejenti eyinkimbinkimbi kanye ne-extractant yokukhipha imvula nokuhlukaniswa kwama-ion ensimbi, ingasebenzisana ne-Cu+ 2, yiba+ 2, Umphathi+ 2, Ca+ 2, Sr+ 2, Ba + 2 kanye ne-Zn+ 2、Cd+2、Al+3、Ga+3、In+3、Tl+3、Yt+3、La +3、Pb+2、B+3、Sb+ 3、Cr+3、I-MoO+ 22Ukuhlanganiswa kwe-Mn+ 2,UFe+ 3, CO+ 2, Ni+ 2, I-PD+ 2, CE+ 3, kanye namanye ama-ion ensimbi. Ukuhlaziywa okuncane kwezinto eziphilayo, okujwayelekile kokunqunywa kwe-heterocyclic nitrogen, ukwakheka kwezinto eziphilayo. Futhi kuyinhlanganisela yamadayi, izibulala-zinambuzane kanye nama-quinolines e-halogenated. Usawoti wayo we-sulfate kanye nowethusi kuyizinto zokugcina izinto ezinhle kakhulu.
3. Ukwengeza inhlaka ye-epoxy resin kungathuthukisa amandla okubopha kanye nokumelana nokuguga kokushisa ezinsimbini (ikakhulukazi insimbi engagqwali), futhi umthamo ngokuvamile u-0.5 ~ 3 phr. Kungumthombo ophakathi wemithi ye-quinoline anti amoeba ene-halogenated, kanye nomthombo ophakathi wemithi yokubulala izinambuzane kanye nodayi. Kungasetshenziswa njengesithibi se-mildew, isilondolozi sezimboni, isiqiniseko se-polyester resin, i-phenolic resin kanye ne-hydrogen peroxide, kanye nesibonakaliso se-complexometric titration sokuhlaziywa kwamakhemikhali.
4. Lo mkhiqizo awugcini nje ngokuba yingxenye yemithi ye-quinoline ene-halogenated, kodwa futhi uyingxenye yedayi nezibulala-zinambuzane. Usawoti wawo we-sulfate kanye nowethusi kuyizinto zokugcina ezinhle kakhulu, izibulala-magciwane kanye nezinto ezilwa nokubola. Okuqukethwe okuphezulu okuvunyelwe (ingxenye enkulu) ezimonyweni zokugcoba kungu-0.3%. Imikhiqizo ye-sunscreen kanye nemikhiqizo yezingane ezingaphansi kweminyaka emi-3 ubudala (njenge-talcum powder) ayivunyelwe, futhi "ayivunyelwe izingane ezingaphansi kweminyaka emi-3 ubudala" kufanele iboniswe kwilebula yomkhiqizo. Lapho kubhekene nesikhumba esitheleleke ngamagciwane kanye ne-bacterial eczema, ingxenye enkulu ye-8-hydroxyquinoline ku-emulsion ingu-0.001% kuya ku-0.02%. Iphinde isetshenziswe njengesibulala-magciwane, isibulala-magciwane kanye ne-bactericide, futhi umphumela wayo wokulwa nokubola unamandla. I-8-hydroxyquinoline potassium sulfate isetshenziswa kukhilimu wokunakekela isikhumba kanye ne-lotion (ingxenye enkulu) kusukela ku-0.05% kuya ku-0.5%.