Izindlela zokuncibilikisa i-HPMC zifaka: indlela yesisombululo esisheshayo samanzi abandayo kanye nendlela yesisombululo esishisayo, indlela yokuxuba i-powder kanye nendlela yokumanzisa i-organic solvent
Isixazululo samanzi abandayo se-HPMC siphathwa nge-glyoxal, esakazeka ngokushesha emanzini abandayo. Ngalesi sikhathi, akusona isisombululo sangempela. Siyisisombululo lapho i-viscosity ikhula. Isixazululo esishisayo asiphathwa nge-glyoxal. Uma umthamo we-glyoxal mkhulu, uzosakazeka ngokushesha, kodwa i-viscosity izokhuphuka kancane.
Njengoba i-HPMC ingancibiliki emanzini ashisayo, i-HPMC ingahlakazeka ngokulinganayo emanzini ashisayo esigabeni sokuqala, bese incibilika ngokushesha lapho ipholile.
Izindlela ezimbili ezijwayelekile zichazwe ngezansi:
1) Faka inani elidingekayo lamanzi ashisayo esitsheni bese ulishisa lifike ku-70 ℃. I-Hydroxypropyl methylcellulose yengezwa kancane kancane ngaphansi kokuxubha kancane, i-HPMC yaqala ukuntanta emanzini, yabe isiqala ukwakheka kancane kancane, okwapholiswa ngaphansi kokuxubha.
2) Faka u-1/3 noma u-2/3 wamanzi adingekayo esitsheni, ufudumale ufike ku-70 ℃, usakaze i-HPMC ngendlela elandelayo: 1) ukulungiselela i-slurry yamanzi ashisayo; Bese ufaka amanzi abandayo asele ku-slurry yamanzi ashisayo, uvuselele bese upholisa ingxube.
I-HPMC esheshayo yamanzi abandayo ingancibilikiswa ngokufaka amanzi ngqo, kodwa isikhathi sokuqala se-viscosity singumzuzu owodwa kuya kwengu-15. Isikhathi sokusebenza akumele sidlule isikhathi sokuqala.
Indlela yokuxuba i-powder: I-HPMC powder ihlakazeka ngokuphelele ngokuxuba okomile ngezingxenye ezifanayo noma ngaphezulu ze-powder, bese incibilikiswa ngamanzi. Kulesi simo, i-HPMC ingancibilikiswa ngaphandle kokuyibeka ekhekheni.
Indlela yokumanzisa i-organic solvent:
I-hydroxypropyl methylcellulose ingancibilikiswa ngokuyihlakaza ibe yi-organic solvent noma ukuyimanzisa nge-organic solvent, bese uyifaka emanzini abandayo noma emanzini abandayo. I-ethanol, i-ethylene glycol, njll. ingasetshenziswa njenge-organic solvent.
Isikhathi sokuthunyelwe: Jan-20-2022